Extended Data Figure 1: Proteostatic crosstalk between mitochondria and the cytosol.
From: A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death
a, Suppression of ρo-lethality in the yme1Δ, atp1Δ, tom70Δ and mgr2Δ mutants by anti-degenerative genes on YPD medium supplemented with ethidium bromide that eliminates mtDNA. b, Schematic depiction of the cytosolic anti-degenerative proteostatic network that suppresses mPOS. c, Synthetic growth defect between yme1Δ and the disruption of anti-degenerative genes (PBP1, RPL40A, SSB1 and POC4) and other genes affecting cytosolic proteostasis (DHH1, BLM10 and RPN4). Cells were grown on YPD medium and incubated at the indicated temperatures.
