Extended Data Figure 6: Transcriptional similarity of the kidney organoid to human fetal organs.
From: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
Dendrogram showing the hierarchical clustering of day 0, 3, 11 and 18 differentiation experiments and 21 human fetal organs from first and second trimester (Gene Expression Omnibus accession number GSE66302)15. Sample name is composed of individual ID followed by an organ name and gestation week. For instance, ‘DJ1 kidney_9’ represents a kidney at ninth week gestation from individual ID: DJ1. Day 0 and 3 kidney organoids cluster with gonad, in agreement with the common origin of both gonad and kidney from the intermediate mesoderm. Day 11 and 18 kidney organoids show strongest similarity to trimester 1 human kidney. The classifier genes used for this analysis are detailed in Supplementary Table 3.
