The cellular process of autophagy has been proposed to help kill Mycobacterium tuberculosis. But although the autophagy gene Atg5 is key to host immunity, other autophagy genes do not affect the outcome of tuberculosis. See Letter p.565
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References
Kimmey, J. M. et al. Nature 528, 565–569 (2015).
Bhatt, K. & Salgame, P. J. Clin. Immunol. 27, 347–362 (2007).
Liu, P. T., Stenger, S., Tang, D. H. & Modlin, R. L. J. Immunol. 179, 2060–2063 (2007).
Fabri, M. et al. Sci. Transl. Med. 3, 104ra102 (2011).
Fabri, M. & Modlin, R. L. Cell Host Microbe 6, 201–203 (2009).
Gutierrez, M. G. et al. Cell 119, 753–766 (2004).
Castillo, E. F. et al. Proc. Natl Acad. Sci. USA 109, E3168–E3176 (2012).
Watson, R. O., Manzanillo, P. S. & Cox, J. S. Cell 150, 803–815 (2012).
Chang, T. K. et al. Nature Cell Biol. 15, 1067–1078 (2013).
Nishida, Y. et al. Nature 461, 654–658 (2009).
Deretic, V., Jiang, S. & Dupont, N. Trends Cell Biol. 22, 397–406 (2012).
Shravage, B. V., Hill, J. H., Powers, C. M., Wu, L. & Baehrecke, E. H. Development 140, 1321–1329 (2013).
Sanjuan, M. A. et al. Nature 450, 1253–1257 (2007).
Behrends, C., Sowa, M. E., Gygi, S. P. & Harper, J. W. Nature 466, 68–76 (2010).
Yousefi, S. et al. Nature Cell Biol. 8, 1124–1132 (2006).
Young, M. M. et al. J. Biol. Chem. 287, 12455–1468 (2012).
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Behar, S., Baehrecke, E. Autophagy is not the answer. Nature 528, 482–483 (2015). https://doi.org/10.1038/nature16324
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DOI: https://doi.org/10.1038/nature16324
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