Extended Data Figure 7: Structural comparison between AtTPC1 VSD2, NavAb VSD (PDB: 3RVY) and Kv1.2-2.1 VSD (PDB: 2R9R)
From: Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana
All structures are aligned at the gating charge transfer centre and S1 helices are removed for clarity. The side chains of the voltage-sensing arginines in S4, residues in gating charge transfer centre and the conserved acidic residue in S2 are shown in stick model. Voltage-sensing residues in gating charge transfer centre are labelled in red. Lower panels are cross-sections of surface-rendered AtTPC1 VSD2 (left) and NavAb VSD (right) with S4 gating charge arginines in blue. NavAb VSD is rotated by 90° to visualize the external aqueous cavity.
