Extended Data Figure 3: Structure of AtTPC1 transmembrane region and its alignment with prokaryotic Nav channels.
From: Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana
a, Structure of the individual 6-TM domain of AtTPC1 in rainbow colour with the same pore orientation. b, Superposition of AtTPC1 (red) and NavRh (blue, PDB: 4DXW). The NavRh VSDs align well with AtTPC1 VSD1s. c, Superposition of AtTPC1 (red) and NavAb (cyan, PDB: 3RVY). The NavAb VSDs align well with AtTPC1 VSD2s. d, Pore superposition between AtTPC1 (red) and NavRh (blue). e, Pore superposition between AtTPC1 (red) and NavAb (cyan).
