Extended Data Figure 3: Linkage disequilibrium relationships (r2) of MHC SNPs to forms of C4 structural variation.
From: Schizophrenia risk from complex variation of complement component 4
a, b, Correlations of SNPs in the MHC locus with copy number of C4 gene types (a) and larger-scale structural forms (haplotypes) (b) of the C4 locus. Dashed, vertical lines indicate the genomic location of the C4 locus. C4 structural forms show only partial correlation (r2) to the allelic states of nearby SNPs, reflecting the relationship shown in Fig. 2, in which a structural form of the C4 locus often segregates on multiple different SNP haplotypes.
