Extended Data Figure 7: Human T1D-relevant pMHCII–NPs, but not free peptide or peptide-coated nanoparticles or microparticles, expand cognate TR1-like CD4+ T cells in human PBMC-engrafted NSG hosts.
From: Expanding antigen-specific regulatory networks to treat autoimmunity
a, FACS profiles (cognate versus control tetramer staining in hCD4+ T cells) of samples from mice identified as responders in Supplementary Table 2. Numerical data on tetramer+ T cells are presented on Supplementary Table 2. b, Representative FACS profiles (cognate versus control tetramer staining in splenic hCD4+ T cells) of human healthy control PBMC-engrafted NSG hosts treated with IGRP13-25/DR3–NPs (left), or human T1D PBMC-engrafted NSG hosts treated with IGRP13–25 peptide, IGRP13–25 peptide-coated nanoparticles, IGRP13–25 peptide-coated microparticles, or left untreated (right). See Fig. 5 legend for details.
