Extended Data Figure 2: Conformational changes of the TM9b and loop E region of MraYAA upon MD2 binding.
From: Structural insights into inhibition of lipid I production in bacterial cell wall synthesis
a, Zoomed-in view of TM9b (yellow) and loop E (salmon) of apoMraYAA, viewed from within the membrane. b, TM9b and loop E of MD2-bound MraYAA viewed from within the membrane. MD2 is omitted to illustrate the conformational change of TM9b and loop E associated with MD2 binding. Conserved amino acid residues and their interactions are shown in stick representation as dotted lines, respectively. c, 45° rotated view of a about a horizontal axis. d, 45° rotated view of b about a horizontal axis, including the model of MD2 (green). The rotation of TM9b and rearrangement of loop E, including the HHH motif, allows for MD2 binding, especially its peptidic moiety.
