Extended Data Figure 8: Mutation rate around TFBS in other cancer types.
From: Nucleotide excision repair is impaired by binding of transcription factors to DNA
Mutation rates around TFBS of promoter regions of lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and colorectal cancer (CRC) are shown. CRC samples are separated into two groups, those with missense mutations of the DNA polymerase epsilon (POL-E) gene or hypermutated (n = 8 samples) and the rest or hypomutated (n = 34 samples). In the left column, the mutation rate is shown for active TFBS that overlap DHS sites (red line) and inactive TFBS that do not overlap DHS (green line). The right column graphs present the mutation rate of six different changes separately in active TFBS. In lung cancers (LUAD and LUSC), C > A changes, caused by tobacco carcinogens, contributes more to the elevated mutation rate, which indicates that NER activity is lower at these active TFBS.
