Extended Data Figure 1: Higher mutation rate at bound TFBS compared to unbound TFBS in melanoma.
From: Nucleotide excision repair is impaired by binding of transcription factors to DNA
The mutation rate is higher in active TFBS (bound by their TF and overlapping DHS; bound-DHS, red line) compared to: (i) inactive TFBS (not overlapping any DHS; bound-noDHS, blue line); and (ii) unbound inactive TFBS (not bound by TF and not overlapping any DHS; unbound-noDHS, orange line). The binding sites considered here correspond to the subset of TFs (n = 58) for which both the bound and unbound motif predictions are available from the ENCODE integrative analysis24. For comparison purposes, we sampled an equal number of unbound-noDHS TFBS (unbound-noDHS sampled, brown line) as in the set of bound-DHS, and confirmed that the mutation rate is still higher in the bound TFBS. The background mutation rates of each group are represented as black lines. The zero coordinate in the x axis corresponds to the TFBS mid-point, and the magenta line above it represents the average size of TFBS.
