Extended Data Figure 2: Elevated mutation rate at the binding sites of individual transcription factors in melanoma.
From: Nucleotide excision repair is impaired by binding of transcription factors to DNA
Here, we show the mutation rate of the TFBS of all TFs with at least 1,000 binding sites overlapping melanocytes DHS. The observed mutation rate is shown in red (light colour in the background corresponds to the actual data points, and the thick solid line on top is the best-fit spline), while the background mutation rate is represented by the black line. The zero coordinate in the x axis corresponds to the TFBS mid-point, and the magenta line above it represents the average size of TFBS.
