Extended Data Figure 4: Regions around TFBS show a decrease in nucleotide excision repair.
From: Nucleotide excision repair is impaired by binding of transcription factors to DNA
Mutation rate around TFBS plotted alongside the average repair of two types of UV-light induced DNA damage—CPD and 6–4PP in wild-type NHF1 cell line of skin fibroblasts and the CS-B mutant cell line for proximal (left column) and distal (right column) TFBS in a. Also, a lower level of nucleotide excision repair is observed at the binding sites of individual transcription factors. For example, the results for CTCF, ETS1, IRF1 and TAF1 are shown in b. In both a and b, the observed mutation rate is shown in red (light colour in the background corresponds to the actual data points, and the thick solid line on top is the best-fit spline). The two top rows show the CPD repair on NHF1 and CS-B cells, respectively and the two bottom rows show the 6–4PP repair on NHF1 and CS-B cells, respectively. Here the average repair levels are shown separately for the forward and reverse strands of the genome (as obtained from ref. 6).
