Extended Data Figure 5: The level of nucleotide excision repair, and the resulting mutation rate in TFBS correlate with the strength of the binding signal of transcription factors to their sites.
From: Nucleotide excision repair is impaired by binding of transcription factors to DNA
Regions around TFBS sites were obtained from ref. 17. As in ref. 17, the binding sites were classified into four quartiles (low to high) using the ChIP-seq read coverage that reflects the strength of binding or occupancy. The binding sites in the ‘high’ quartile (fourth column) tend to bear higher mutation rates at the centre (correlating with lower repair) compared to the ‘low’ quartile (first column). The nucleotide excision repairs of two photoproducts (CPD and 6–4PP) shown here are from NHF1 wild-type cell line. Average repair levels are shown separately for the forward and reverse strands of the genome (as obtained from ref. 6).
