Extended Data Figure 9: (2R,6R)-HNK administration does not alter startle amplitude, drug discrimination rate or self-administration drug intake.
From: NMDAR inhibition-independent antidepressant actions of ketamine metabolites
a, Startle amplitude as measured in the pre-pulse inhibition task was not affected by administration of (R,S)-KET or (2R,6R)-HNK. b, c, Response rate of overall lever pressing per sec in the drug discrimination model was not changed by administration of (R,S)-KET, (2R,6R)-HNK (b) or PCP (c). d, Unlike ketamine, (2R,6R)-HNK did not alter drug intake in the self-administration task in mice. Data are mean ± s.e.m. *P < 0.05 (see Supplementary Table 1 for statistical analyses and n numbers).
