Extended Data Figure 2: Circulating levels of ketamine and its metabolites following i.p. administration in mice.
From: NMDAR inhibition-independent antidepressant actions of ketamine metabolites
a, b, Plasma (a) and brain (b) levels of ketamine and its metabolites after administration of (R,S)-KET (10 mg kg−1) in mice. c, d, Brain levels of KET (c), norKET (d) and HNK (e) following administration of (S)- and (R)-KET. f, g, Chemical structure of (R,S)-6,6-dideuteroketamine ((R,S)-d2-KET) (f), which displaces [3H]MK-801 binding with a similar affinity to (R,S)-KET ((R,S)-KET: Ki = 799 nM; (R,S)-d2-KET: Ki = 883 nM) (g). See Supplementary Table 1 for statistical analyses and n numbers.
