Extended Data Figure 4: Locomotor effects of (R,S)-KET and (R,S)-d2-KET.
From: NMDAR inhibition-independent antidepressant actions of ketamine metabolites
After recording baseline activity for 60 min, mice received drug (marked by a vertical dashed line) and locomotor activity was monitored for another 1 h. a, b, Administration of (R,S)-KET (10 mg kg−1), induced hyperlocomotor responses equally in both male and female mice. c, d, (R,S)-KET and (R,S)-d2-KET were equally potent in inducing a hyperlocomotor response at the dose of 10 mg kg−1. Data are mean ± s.e.m. *P < 0.05, **P < 0.01 (see Supplementary Table 1 for statistical analyses and n numbers).
