Extended Data Figure 10: Graphical summary of the AMPK–SKP2–CARM1 signalling cascade.
From: AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
Proposed model depicting the AMPK–SKP2–CARM1 signalling axis in the transcriptional and epigenetic regulation of autophagy. The SKP2-containing SCF E3 ubiquitin ligase complex degrades CARM1 under nutrient-rich conditions, but in nutrient-deprived conditions, AMPK-dependent phosphorylation of FOXO3a downregulates SKP2 and stabilizes CARM1, which in turn functions as a co-activator of TFEB in regulation of autophagy.
