Table 1 ZIKV-specific neutralizing antibody titers

From: Vaccine protection against Zika virus from Brazil

Vaccine

ZIKV MN50 titer

DNA prM-Env

22

DNA prM-Env(ΔTM)

<10

DNA prM-Env(Δstem)

<10

DNA Env

<10

DNA Env(ΔTM)

<10

DNA Env(Δstem)

<10

DNA prM-Env + boost

1,022

PIV + alum i.m.

15

PIV + alum s.c.

15

Sham + alum i.m.

<10

Sham + alum s.c.

<10

Anti-flavivirus antibody

232

  1. Balb/c mice received a single immunization with 50 μg of various DNA vaccines (Figs 1, 2) or 1 μg purified inactivated virus (PIV) vaccines with alum (Fig. 4), and pooled serum was assessed for ZIKV-specific neutralizing antibodies at week 4. 50% microneutralization (MN50) titers are shown. Also shown are MN50 titers in serum from mice following two immunizations with DNA-prM-Env (boost) and an anti-flavivirus human polyclonal antibody.
Back to article page