Extended Data Figure 4: EMT features in Fh1-deficient cells are independent of HIF.
From: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
mRNA levels of EMT genes and Hif1β (a) and HIF target genes (b) in Fh1−/− cells infected with shRNA against Hif1β measured by qPCR. Results were obtained from three independent cultures and presented as RQ with maximum values using Actb as endogenous control. P values from unpaired t-test are indicated. Glut1 also known as Slc2a1. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. Source data are presented in Supplementary Table 2.
