Figure 1: Somatic alterations in cervical cancer and associations with molecular platform features.
From: Integrated genomic and molecular characterization of cervical cancer
a–d, Cervical carcinoma samples ordered by histology and mutation frequency (a), clinical and molecular platform features (b), SMGs (c), and select somatic copy number alterations (d) are presented. SMGs are ordered by the overall mutation frequency and colour-coded by mutation type. Novel SMGs identified in squamous cell carcinomas are labelled in turquoise text. The number of APOBEC signature mutations (red) and other mutations (blue) present in every SMG is plotted to the right of the SMG panel and the number of gene-level somatic copy number alterations across all genes is plotted as gain (red) and loss (blue) to the right of the somatic copy number alteration panel. CN, copy number; SCNAs, somatic copy number alterations; Adeno., adenocarcinomas; Adenosq., adenosquamous cancers; Squamous, squamous cell carcinomas.
