Extended Data Figure 5: Unsupervised clusters of DNA methylation data.
From: Integrated genomic and molecular characterization of cervical cancer
a, Heatmap showing β values of 178 core-set samples ordered by CIMP clusters. Samples are presented in columns and the CpG island promoter CpG loci are presented in rows. An annotation panel on the right of the heatmap indicates CpG loci that are differentially methylated within a particular feature (see Supplementary Table 13). All features (marked with an asterisk) are significantly associated with DNA-methylation clusters (Fisher’s Exact test P < 0.01), except APOBEC mutagenesis level, UCEC-like status and HPV integration status. b, Box plots of the EMT mRNA score and tumour purity by CIMP clusters. *P < 0.05; **P < 0.01 (Student’s t-test).
