Extended Data Figure 9: miR-200a/b associations with EMT-regulating genes and somatic alterations within RTK, PI3K, MAPK and TGFβR2 pathways in cervical cancer.
From: Integrated genomic and molecular characterization of cervical cancer
a, Expression levels for miR-200a and miR-200b compared to DNA-methylation level at their promoter. Samples were called altered if the miRNAs were concurrently hypermethylated (β > 0.3) and downregulated (red). b, mRNA expression levels for ZEB2, a target of both miR-200a and miR-200b, in subsets of miR-200a/b altered samples. ZEB2 is upregulated in samples with concurrent hypermethylation and downregulation of the miRNAs. c, mRNA expression levels of both ZEB1 and ZEB2 in miR-200a/b hypermethylated/downregulated (altered) and all other (WT) samples. d, Correlations of miR-200a and miR-200b expression with multiple genes involved in EMT signalling across squamous cell carcinomas and adenocarcinomas. e, Extent of genetic alterations and miRNA downregulation in the RTK, PI3K, MAPK and TGFβ pathways across all cervical tumours.
