Extended Data Figure 10: Pathway biomarkers differentiating squamous cell carcinomas and adenocarcinomas.
From: Integrated genomic and molecular characterization of cervical cancer
a, Cytoscape display of the largest interconnected regulatory network of PARADIGM pathway features that are differentially activated between squamous cell carcinomas and adenocarcinomas connected through hubs with ≥10 downstream targets. Hubs with ≥10 downstream targets are labelled. Genes showing mRNA–miRNA expression anti-correlation with strong supporting evidence are highlighted with a thicker black outline and are labelled. Top differentially expressed genes relating to immune function are also labelled. Node size is proportional to significance of differential activation. b, Zoom-in display of the p63 sub-network neighbourhood. First neighbours (upstream or downstream) of four p63 complexes (bold text) are displayed in this view.
