Extended Data Figure 11: HPV integration and molecular characteristics in cervical cancer.
From: Integrated genomic and molecular characterization of cervical cancer
a, E6 unspliced/spliced ratio for HPV16 and HPV18 intragenic, enhancer and intergenic sites. HPV16, median = 0.44 (n = 102); HPV18, median = 0.93 (n = 40). The P value is from a two-sided Kolmogorov–Smirnov test. b, Distribution of RNA-seq-based EMT score for HPV-negative (HPV−) and HPV-positive (HPV+) samples (n = 178). The P value was calculated as in a. c, Distributions of somatic copy number alterations and mRNA abundance ranks (left) and distribution functions for somatic copy number alterations and mRNA abundance ranks with 500 random samples shown close to the diagonals (grey) (right) for genomic loci with integrated HPV16. d, Distributions as in c for genomic loci with integrated HPV18. Benjamini–Hochberg-corrected P values for the somatic copy number alteration and mRNA abundance ranks are medians of the P values from Kolmogorov–Smirnov tests for all random samples.
