Figure 4: Mutual exclusivity of somatic alterations within the PI3K–MAPK and TGFβR2 pathways.
From: Integrated genomic and molecular characterization of cervical cancer
a, Multiple alterations affect RTK, AKT and MAPK signalling in both squamous cell carcinomas and adenocarcinomas. A schematic diagram of the pathways is shown for altered genes along with the percentage of alteration in squamous cell carcinomas and adenocarcinomas. Significant P values (P < 0.05, Student’s t-test) for alteration frequency differences between squamous cell carcinomas and adenocarcinomas are listed at the gene level, with significantly different genes marked with an asterisk. b, Distinct types of alterations (amplification, deletion, missense mutation and truncating mutation) affect genes (rows) in these pathways in each sample (columns). c, TGFβ signalling is frequently altered in cervical tumours. Alterations in this pathway are divided between those probably affecting TGFβ-tumour-suppressive functions and those affecting the TGFβ-driven EMT program. d, Samples with alterations targeting TGFβ-tumour-suppressive functions do not show significantly different EMT scores compared with all other samples; however, samples with low expression/high methylation of miR-200a/b have significantly higher EMT scores than all other samples. miR-down, samples met double threshold of methylated and downregulated as described in Methods. NS, not significant. Percentages in b and d, indicate per cent of the total histological subgroup population.
