Figure 5: HPV integration and differential pathway activation between HPV subtypes.
From: Integrated genomic and molecular characterization of cervical cancer
a, Cytoscape display of the largest interconnected regulatory network of PARADIGM integrated pathway level (IPL) features showing differential inferred activation between HPV A9 and A7 squamous carcinomas (n = 101 and n = 35, respectively). Node colour and intensity reflect the level of differential activation. Node size represents level of significance. SFN is within a subnetwork identified by functional epigenetic module analysis (Supplementary Information 13) as disrupted between HPV A9 and A7 squamous cell carcinomas, and is highlighted using a bold black outline. rRNA, ribosomal RNA. DST, DST isoform 3. b, Circos plot showing frequency (0–100%) of gains and losses for regions of each chromosome (outer circle). Lines within the inner circle indicate integration breakpoints from the HPV genome (L1, L2, E1, E2, E4, E5, E6 and E7 genes) to the human genome as defined in Methods, Supplementary Information 2, and Supplementary Table 3. Lines are colour coded by HPV clade.
