Extended Data Figure 1: Chemical structure of ABL001 and biophysical characterization of its binding. | Nature

Extended Data Figure 1: Chemical structure of ABL001 and biophysical characterization of its binding.

From: The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1

Extended Data Figure 1: Chemical structure of ABL001 and biophysical characterization of its binding.

a, Chemical structure of ABL001. b, NMR chemical shift assay to determine the location of ABL001 binding. c, NMR-based conformational assay using the resonance of Val525 to monitor the ‘bending’ of helix I in the presence and absence of ABL001. d, Isothermal calorimetry study to determine the binding affinity (Ka) of ABL001 to ABL1.

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