Extended Data Figure 7: Series of events that take place in BIR compared to gene conversion.
From: Rad51-mediated double-strand break repair and mismatch correction of divergent substrates
Left, in BIR, we exclusively measure mismatch correction of heteroduplex DNA (dashed box) formed during the initial strand invasion. Right, in gene conversion, sequences copied from the donor by extending the invading strand may extend well beyond half the length of the homology on the second end. Annealing between this extended end and the resected second end (second-end capture) would result in heteroduplex DNA (dashed box). For simplicity, only two mismatches are shown. Mismatch correction in gene conversion studies therefore could be a combination of correction in the context of invasion and second-end capture.
