Extended Data Figure 8: Comparisons of an inactive CTR homology model and the activate CTR structure.
From: Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
a, Side view of the activate sCT–CTR–Gs complex transmembrane structure (blue) relative to the inactive CTR homology model (red). b, Tube representation for transmembrane domains showing extracellular (top) and cytoplasmic (bottom) views of the activate sCT–CTR–Gs complex transmembrane structure (blue) relative to the inactive CTR homology model (red). In a and b large differences are observed at the extracellular ends of TM6 and TM7, with additional differences within TM1 and TM5. In addition, a very large outward movement is observed within TM6 of the active structure relative to the inactive homology model at the intracellular face. c, The positions of class B conserved polar residues located within the inactive CTR homology model.
