Extended Data Figure 3: Somatically mutated and conserved regions in the LAIR1 domains inserted in the VDJ or in the switch region.
From: Public antibodies to malaria antigens generated by two LAIR1 insertion modalities
a, Amino acid substitutions in antibodies isolated from different donors and mean R/S ratios at each residue. The mutational analysis takes into consideration the germline LAIR1 alleles found in each donor. In donor C, the P98L substitution is uncoloured because it may arise from polymorphism, since the donor is heterozygous at this position. The number of nucleotide mutations and amino acid substitutions are reported in brackets next to the antibody names. b, Graphic representation of mutational hot spots (red) and of most conserved regions (blue).
