Extended Data Figure 2: Absolute mutational spectra as a function of parents’ ages at conception.
From: Parental influence on human germline de novo mutations in 1,548 trios from Iceland
a, Phased DNMs from both parents. b, DNMs from mothers. The mutations were aggregated per year, and parent age groups with only one proband were excluded. The numbers of probands per aggregate year were used as weights for linear regression. We restricted results to 225 three-generation probands for this figure. The y axes are different for a and b. The grey areas in a and b represent 95% confidence intervals using a normal approximation.
