Extended Data Figure 8: False discovery rate and sensitivity in network reconstruction based on QMP and RMP simulated data.
From: Quantitative microbiome profiling links gut community variation to microbial load
QMP resulted in increased sensitivity and decreased FDR compared to RMP (two-sided t-test, P < 10−15). For a two-, four- and eightfold maximum difference in microbial load, QMP FDRs were 11%, 15%, and 22% lower, respectively, than for RMP; and QMP true positive discovery rate (sensitivity) was increased by 10%, 12%, and 15%. Data points depict repetitions (n = 50). The body of the box plot represents the first and third quartiles of the distribution and the median line. The whiskers extend from the quartiles to the last simulated data point within 1.5× interquartile range.
