Extended Data Figure 9: ATP-synthase inhibition prevents the reduction in mitochondrial membrane potential in proximal oocytes and blocks aggregate clearance.
From: A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
a, Real-colour and heatmap images of DiOC6(3)-stained germlines after RNAi of genes encoding ATP synthase subunits. b, c, Aggregation-prone proteins in control (ethanol solvent)- or oligomycin-treated hermaphrodites. Percentage of animals with oocyte protein aggregation. Mean ± s.d. from three biological replicates, each of n = 50 animals. ****P < 0.0001. d, LysoTracker reveals lysosome acidification in GFP::RHO-1-expressing hermaphrodites following asb-1 knockdown. Dotted line, intestine. Bars, 10 μm.
