Extended Data Figure 10: Activation of germ cell metabolism.
From: A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
a, Immature germ cells arrest with a high ATP:ADP ratio and a high energy charge, which are reversed in response to sperm signals as ADP levels rise and unlock the ATP synthase. These changes reflect a shift from a resting to an active metabolic state22,23. b, 488 nm-excited fluorescence of PercevalHR and cpmVenus. c, Heatmap of the PercevalHR λhigh/λlow ratio after vha-13 knockdown. d, Peredox fluorescence in a hermaphrodite germline, with line profiles. e, f, GFP::GLD-1 and mitochondrial morphology in ADP- or vehicle-injected female oocytes. Bars, 10 μm.
