Extended Data Figure 8: Effector molecule loci are demethylated during differentiation of virus-specific Dnmt3a cKO CD8 T cells.
From: Effector CD8 T cells dedifferentiate into long-lived memory cells
a, Heat-map representation of top 3,000 demethylated regions in wild-type and Dnmt3a cKO effector CD8 T cell WGBS datasets relative to the naive WGBS dataset. b, Normalized effector loci methylation at CpG sites in the Ifng, Prf1, and Gzmk loci from wild-type and Dnmt3a cKO WGBS datasets. c, Representative FACS analysis of Tbet, Eomes, and Ki67 expression of gp33-specific effector CD8 T cells. d, Representative FACS analysis of cytokine production from virus-specific memory CD8 T cells following 5 h of ex vivo gp33 peptide stimulation.
