Extended Data Figure 9: L-selectinlo MP effector CD8 T cells develop into Tcm CD8 T cells.
From: Effector CD8 T cells dedifferentiate into long-lived memory cells
a, Representative FACS analysis of L-selectin expression on Thy1.1+ CFSE+ MP and TE CD8 T cells 1 day after transfer into naive recipient mice. The limit of our detection was approximately 10–20 CD62L+ cells in each of the lymphoid and nonlymphoid tissues at 1 day post-transfer. b, Summary of number of transferred TE and MP CD8 T cells in the spleen, blood, lymph node, IEL (intraepithelial lymphocytes), lung, and liver of the recipient mice 1 day post-transfer. c, Summary of per cent undivided (undiluted CFSE) L-selectin-positive virus-specific memory CD8 T cells arising from adoptively transferred MP versus TE cells. Data are from three independent experiments. d, Representative post-sort purity FACS analysis of undivided L-selectinhi and L-selectinlo MP P14 cells 28 days after adoptive transfer.
