Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Do targets limit antibiotic discovery?

Nature Biotechnology volume 24, pages 419–420 (2006)Cite this article

An integrative approach highlights the challenge of identifying new antibiotic drug targets.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Starting with 2,200 Salmonella proteins with metabolic functions, Becker et al. use various criteria to select promising targets found in a broad spectrum of pathogens.

Bob Crimi

References

  1. DiMasi, J.A. et al. J. Health Econ. 22, 151–185 (2003).

    Article  Google Scholar 

  2. Becker, D. et al. Nature 440, 303–307 (2006).

    Article  CAS  Google Scholar 

  3. Payne, D.J. et al. Antimicrob. Agents Chemother. 46, 3118–3124 (2002).

    Article  CAS  Google Scholar 

  4. Hajduk, P.J. et al. J. Med. Chem. 48, 2518–2525 (2005).

    Article  CAS  Google Scholar 

  5. Benton, B.M. et al. J. Bacteriol. 186, 8478–8489 (2004).

    Article  CAS  Google Scholar 

  6. Gentry, D.R. et al. Antimicrob. Agents Chemother. 47, 1784–1789 (2003).

    Article  CAS  Google Scholar 

  7. Phillips, O.A. Curr. Opin. Investig. Drugs 6, 768–780 (2005).

    CAS  PubMed  Google Scholar 

  8. http://www.ciprousa.com/

  9. Datamonitor. Market Dynamics Antibacterials: Strategies for a Saturated Market <http://www.datamonitor.com/∼a014b2ea6fbc47e1a922b0edfa778abb∼/industries/research/?pid=DMHC1799&type=Report> (2002).

Download references

Author information

Authors and Affiliations

  1. Keck Graduate Institute, 535 Watson Drive, Claremont, 91711, California, USA

    Molly B Schmid

Authors
  1. Molly B Schmid
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schmid, M. Do targets limit antibiotic discovery?. Nat Biotechnol 24, 419–420 (2006). https://doi.org/10.1038/nbt0406-419

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nbt0406-419

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing