Programmable ribozymes that can attach non-natural amino acids to specific tRNAs may expand the range of amino acids available for protein engineering.
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References
Bessho, Y., Hodgson, D.R.H. & Suga, H. Nat. Biotechnol. 20, 723–728 (2002).
Wong, J.T. Proc. Natl. Acad. Sci. USA 80, 6303–6306 (1983).
van Hest, J.C.M., Kiick, K.L. & Tirrell, D.A. J. Am. Chem. Soc. 122, 1282–1288 (2000).
Döring, V. et al. Science 292, 501–504 (2001).
Wang, L., Brock, A., Herberich, B. & Schultz, P.G. Science 292, 498–500 (2001).
Heckler, T.G. et al. Biochemistry 23, 1468–1473 (1984).
Cornish, V.W., Mendel, D. & Schultz, P.G. Angew. Chem. Int. Ed. Engl. 34, 621–633 (1995).
Piccirilli, J.A. et al. Science 256, 1420–1424 (1992).
Schimmel, P. & Ribas de Pouplana, L. Cell 81, 983–986 (1995).
Illangasekare, M., Sanchez, G., Nickles, T. & Yarus, M. Science 267, 643–647 (1995).
Lohse, P.A. & Szostak, J.W. Nature 381, 442–444 (1996).
Cusack, S. Curr. Opin. Struct. Biol. 9, 66–73 (1999).
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Tamura, K., Schimmel, P. Ribozyme programming extends the protein code. Nat Biotechnol 20, 669–670 (2002). https://doi.org/10.1038/nbt0702-669
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DOI: https://doi.org/10.1038/nbt0702-669