Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Biophysical chemistry

Unravelling capsid transformations

The interactions between a virus capsid and its cargo are essential for viral infection as well as in the design of synthetic virus-like particles. Now a combination of analytical techniques has unravelled key steps in the transformation of a model virus and the release of its RNA cargo.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Untangling heterogeneous populations of a virus with mass spectrometry (MS) and atomic force microscopy (AFM).

References

  1. Suttle, C. A. Nature 437, 356–361 (2005).

    Article  CAS  Google Scholar 

  2. Bloomer, A. C., Champness, J. N., Bricogne, G., Staden, R. & Klug, A. Nature 276, 362–368 (1978).

    Article  CAS  Google Scholar 

  3. Harrison, S. C., Olson, A. J., Schutt, C. E., Winkler, F. K. & Bricogne, G. Nature 276, 368–373 (1978).

    Article  CAS  Google Scholar 

  4. Johnson, J. E. & Chiu, W. Curr. Opin. Struct. Biol. 10, 229–235 (2000).

    Article  CAS  Google Scholar 

  5. Snijder, J. et al. Nature Chem. 5, 502–509 10.1038/nchem.1627(2013).

    Article  CAS  Google Scholar 

  6. Siuzdak, G. et al. Chem. Biol. 3, 45–48 (1996).

    Article  CAS  Google Scholar 

  7. Benesch, J. L. P., Ruotolo, B. T., Simmons, D. A. & Robinson, C. V. Chem. Rev. 107, 3544–3567 (2007).

    Article  CAS  Google Scholar 

  8. Heuvel, R. H. v. d. & Heck, A. J. Curr. Opin. Chem. Biol. 8, 519–526 (2004).

    Article  Google Scholar 

  9. Michel, J. P. et al. Proc. Natl Acad. Sci. USA 103, 6184–6189 (2006).

    Article  CAS  Google Scholar 

  10. Douglas, T. & Young, M. Science 312, 873–975 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Trevor Douglas.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Uchida, M., Douglas, T. Unravelling capsid transformations. Nature Chem 5, 444–445 (2013). https://doi.org/10.1038/nchem.1666

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nchem.1666

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing