The interactions between a virus capsid and its cargo are essential for viral infection as well as in the design of synthetic virus-like particles. Now a combination of analytical techniques has unravelled key steps in the transformation of a model virus and the release of its RNA cargo.
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References
Suttle, C. A. Nature 437, 356–361 (2005).
Bloomer, A. C., Champness, J. N., Bricogne, G., Staden, R. & Klug, A. Nature 276, 362–368 (1978).
Harrison, S. C., Olson, A. J., Schutt, C. E., Winkler, F. K. & Bricogne, G. Nature 276, 368–373 (1978).
Johnson, J. E. & Chiu, W. Curr. Opin. Struct. Biol. 10, 229–235 (2000).
Snijder, J. et al. Nature Chem. 5, 502–509 10.1038/nchem.1627(2013).
Siuzdak, G. et al. Chem. Biol. 3, 45–48 (1996).
Benesch, J. L. P., Ruotolo, B. T., Simmons, D. A. & Robinson, C. V. Chem. Rev. 107, 3544–3567 (2007).
Heuvel, R. H. v. d. & Heck, A. J. Curr. Opin. Chem. Biol. 8, 519–526 (2004).
Michel, J. P. et al. Proc. Natl Acad. Sci. USA 103, 6184–6189 (2006).
Douglas, T. & Young, M. Science 312, 873–975 (2006).
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Uchida, M., Douglas, T. Unravelling capsid transformations. Nature Chem 5, 444–445 (2013). https://doi.org/10.1038/nchem.1666
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DOI: https://doi.org/10.1038/nchem.1666