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Suppression of Graft versus Host Reaction by Univalent Anti-immunoglobulin Antibody

Abstract

THE secondary response of spleen cells of mice immunized with hapten-protein conjugates can be inhibited if the spleen cells are incubated with rabbit serum to mouse immunoglobulin before stimulation by hapten-protein conjugate1. These findings, together with evidence2–4 for the presence of immunoglobulin on the surface of lymphocytes, have fostered the hypothesis of the immune receptor as an antibody-like molecule at the cell membrane of lymphocytes.

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RIETHMÜLLER, G., RIEBER, EP. & SEEGER, I. Suppression of Graft versus Host Reaction by Univalent Anti-immunoglobulin Antibody. Nature New Biology 230, 248–250 (1971). https://doi.org/10.1038/newbio230248a0

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