Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Enzymatic Basis for Platelet: Collagen Adhesion as the Primary Step in Haemostasis

Abstract

The formation of an enzyme-acceptor complex as the effective intermediate in platelet: collagen adhesion provides a simple model for studying the primary step in haemostasis and may provide a rational basis for the design of anti-thrombogenic drugs.

This is a preview of subscription content, access via your institution

Access options

Similar content being viewed by others

References

  1. Kjaerheim, Å., and Hovig, T., Throne. Diath. Haemorrhag., 7, 1 (1962).

    CAS  Google Scholar 

  2. Spaet, T. H., and Zucker, M. B., Amer. J. Physiol., 206, 1267 (1964).

    Article  CAS  Google Scholar 

  3. O'Brien, J. R., Ann. Rev. Med., 17, 275 (1966).

    Article  CAS  Google Scholar 

  4. Madoff, M. A., Ebbe, S., and Baldini, M., J. Clin. Invest., 43, 870 (1964).

    Article  CAS  Google Scholar 

  5. Salzman, E. W., and Chambers, D. A., Nature, 206, 727 (1965).

    Article  CAS  Google Scholar 

  6. Spaet, T. H., in Biochemistry of Blood Platelets (edit. by Kowalski, E., and Niewiarowski, S.), 95 (Academic Press, New York, 1967).

    Google Scholar 

  7. Spiro, R., J. Biol. Chem., 244, 602 (1969).

    CAS  PubMed  Google Scholar 

  8. Butler, W. T., and Cunningham, L. W., J. Biol. Chem., 241, 3882 (1966).

    CAS  PubMed  Google Scholar 

  9. Barber, A. J., and Jamieson, G. A., Fed. Proc., 30, 540 (1971).

    Google Scholar 

  10. Barber, A. J., and Jamieson, G. A., J. Biol. Chem., 245, 6357 (1970).

    CAS  PubMed  Google Scholar 

  11. Spiro, R. G., and Spiro, M. J., Fed. Proc., 27, 345 (1968).

    Google Scholar 

  12. Barker, A. J., and Jamieson, G. A., Biochim. Biophys. Acta (in the press).

  13. Al-Mondhiry, H., and Spaet, T. H., Proc. Soc. Exp. Biol. Med., 135, 878 (1970).

    Article  CAS  Google Scholar 

  14. Wilner, G. D., Nossel, H. L., and LeRoy, E. C., J. Clin. Invest., 47, 2616 (1968).

    Article  CAS  Google Scholar 

  15. Wilner, G. D., Nossel, H. L., and LeRoy, E. C., J. Clin. Invest., 47, 2608 (1968).

    Article  CAS  Google Scholar 

  16. Legrand, Y., Caen, J. P., and Robert, L., Proc. Soc. Exp. Biol. Med., 127, 941 (1968).

    Article  CAS  Google Scholar 

  17. Evans, G., Packham, M. A., Nishizawa, E. E., Mustard, J. F., and Murphy, E. A., J. Exp. Med., 128, 877 (1968).

    Article  CAS  Google Scholar 

  18. Bowie, E. J. W., and Owen, C. A., Circulation, 40, 757 (1969).

    Article  CAS  Google Scholar 

  19. Mustard, J. F., and Packham, M. A., Pharmacol. Rev., 22, 97 (1970).

    CAS  PubMed  Google Scholar 

  20. Spaet, T. H., and Lejnieks, I., Proc. Soc. Exp. Biol. Med., 132, 1038 (1969).

    Article  CAS  Google Scholar 

  21. Hugues, J., and Mahieu, P., Thromb. Diath. Haemorrhag., 24, 295 (1970).

    Google Scholar 

  22. Spiro, R. G., J. Biol. Chem., 242, 4813 (1967).

    CAS  PubMed  Google Scholar 

  23. Zucker, M. B., and Borelli, J., Proc. Soc. Exp. Biol. Med., 109, 779 (1962).

    Article  Google Scholar 

  24. Einbinder, J., and Schubert, M., J. Biol. Chem., 188, 335 (1951).

    CAS  PubMed  Google Scholar 

  25. Roseman, S., Chem. Phys. Lipids, 5, 270 (1970).

    Article  CAS  Google Scholar 

  26. Caccam, J. F., Jackson, J. J., and Eylar, E. H., Biochem. Biophys. Res. Commun., 35, 505 (1969).

    Article  CAS  Google Scholar 

  27. Tetas, M., Chao, H., and Molnar, J., Arch. Biochem. Biophys., 138, 135 (1970).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

JAMIESON, G., URBAN, C. & BARBER, A. Enzymatic Basis for Platelet: Collagen Adhesion as the Primary Step in Haemostasis. Nature New Biology 234, 5–7 (1971). https://doi.org/10.1038/newbio234005a0

Download citation

  • Received:

  • Issue date:

  • DOI: https://doi.org/10.1038/newbio234005a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing