Abstract
Colicin E3 is shown to cleave 16S ribosomal RNA of Escherichia coli cells directly, rather than as previously believed by an indirect mechanism initiated by binding of E3 to the cell membrane. Specific immunity conferred on cells that harbour the E3 Col factor is explained in terms of an inhibitor of E3 cleavage reaction found only in colicinogenic cells.
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BOWMAN, C., SIDIKARO, J. & NOMURA, M. Specific Inactivation of Ribosomes by Colicin E3 in vitro and Mechanism of Immunity in Colicinogenic Cells. Nature New Biology 234, 133–137 (1971). https://doi.org/10.1038/newbio234133a0
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DOI: https://doi.org/10.1038/newbio234133a0
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