Abstract
The structure of human immunoglobulin Fab′ fragment has been elucidated at a resolution of 6 Å. There are two globular subunits, which presumably correspond to the variable and constant regions of the heavy and light polypeptide chains of immunoglobulins
This is a preview of subscription content, access via your institution
Access options
Similar content being viewed by others
References
Milstein, C., and Pink, J. R. L., Prog. Biophys. Mol. Biol. (edit. by Butler, J. A. V., and Noble, D.), 21, 211 (Pergamon, Oxford and New York, 1970).
Edelman, G. M., and Gall, W. E., Ann. Rev. Biochem., 38, 415 (1969).
Smith, G. P., Hood, L., and Fitch, W. M., Ann. Rev. Biochem., 40, 969 (1971).
Dorrington, K. J., and Tanford, C., Adv. Immunol, 12, 333 (1970).
Sarma, V. R., Silverton, E. W., Davies, D. R., and Terry, W. D., J. Biol. Chem., 246, 3753 (1971).
Edmundson, A. B., Wood, M. K., Schiffer, M., Hardman, K. D., Ainsworth, C. F., and Ely, K. R., J. Biol. Chem., 245, 2763 (1970).
Schiffer, M., Hardman, K. D., Wood, M. K., Edmundson, A. B., Hook, M. E., Ely, K. R., and Deutsch, H. F., J. Biol. Chem., 245, 728 (1969).
Solomon, A., McLaughlin, C. L., Wei, C. H., and Einstein, J. R., J. Biol. Chem., 245, 5289 (1970).
Rossi, G., Choi, T. K., and Nisonoff, A., Nature, 223, 837 (1969).
Poljak, R. J., Amzel, L. M., Avey, H. P., Becka, L. N., Goldstein, D. J., and Humphrey, R. L., Cold Spring Harbor Symp. Quant. Biol., 36 (in the press).
Blow, D. M., and Crick, F. H. C., Acta Cryst., 12, 794 (1959).
Valentine, R. C., and Green, N. M., J. Mol. Biol., 27, 615 (1967).
Labaw, L. W., and Davies, D. R., J. Biol. Chem., 246, 3760 (1971).
Green, N. M., Dourmashkin, R. R., and Parkhouse, R. M. E., J. Mol. Biol., 56, 203 (1971).
Solomon, A., and McLaughlin, C. L., J. Biol. Chem., 244, 3393 (1969).
Karlsonn, F. A., Peterson, P. A., and Berggard, I., Proc. US Nat. Acad. Sci., 64, 1257 (1969).
Bjork, I., and Tanford, C., Biochemistry, 10, 1271 (1971).
Hill, R. L., Delaney, R., Fellow, jun., R. E., and Lebowitz, H. E., Proc. US Nat. Acad. Sci., 56, 1762 (1966).
Edelman, G. M., Cunningham, B. A., Gall, W. E., Gottlieb, P. D., Rutishauser, V., and Waxdal, M. J., Proc. US Nat. Acad. Sci., 63, 78 (1969).
Welscher, H. D., Intern. J. Protein Res., 1, 267 (1969).
Singer, S. J., Slobin, L. I., Thorpe, N. O., and Fenton, J. W., Cold Spring Harbor Symp. Quant. Biol., 32, 99 (1967).
Goldstein, D. J., Humphrey, R. L., and Poljak, R. J., J. Mol. Biol., 35, 247 (1968).
Cullis, A. F., Muirhead, H., Perutz, M. F., Rossmann, M. G., and North, A. C. T., Proc. Roy. Soc., A, 265, 15 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
POLJAK, R., AMZEL, L., AVEY, H. et al. Structure of Fab New at 6 Å Resolution. Nature New Biology 235, 137–140 (1972). https://doi.org/10.1038/newbio235137a0
Received:
Revised:
Issue date:
DOI: https://doi.org/10.1038/newbio235137a0
This article is cited by
-
Three-dimensional structure of an antigen–antibody complex at 6 Å resolution
Nature (1985)
-
Three-dimensional structure, function and genetic control of immunoglobulins
Nature (1975)
-
Structure at 4.5 Å; Resolution of a Phosphorylcholine-binding Fab
Nature New Biology (1973)
-
Weitere Untersuchungen an einem kristallisierten humanen Immunglobulin von monoklonalem Ursprung
Monatshefte f�r Chemie (1973)
-
Gene Duplication in Carp Muscle Calcium Binding Protein
Nature New Biology (1972)


