Abstract
THE regulation of bile salt synthesis in man is still poorly understood. The human liver synthesizes a trihydroxy and a dihydroxy bile acid, cholic and chenodeoxycholic acid, each conjugated with glycine or taurine. These, together with deoxycholic acid, a dihydroxy bile acid which results from the 7-α dehydroxylation of cholic acid by intestinal bacteria, constitute approximately 98% of the bile salt pool which circulates enterohepatically during digestion of a meal1. Lindstedt found that the composition of the bile salt pool varies little from day to day in any one individual2, and this has also been our experience on analysis of 48 bile samples collected on different days from 16 volunteers. However, the evidence that bile salt synthesis is regulated by a negative feedback mechanism is scanty3 apart from the increased synthesis that follows interruption of the enterohepatic circulation4–6.
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References
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LOW-BEER, T., POMARE, E. & MORRIS, J. Control of Bile Salt Synthesis. Nature New Biology 238, 215–216 (1972). https://doi.org/10.1038/newbio238215a0
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DOI: https://doi.org/10.1038/newbio238215a0
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