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Epstein-Barr Virus-associated Antigens in Non-producing Clones of Human Lymphoblastoid Cell Lines

Nature New Biology volume 239, pages 242–243 (1972)Cite this article

Abstract

NUCLEIC acid hybridization suggests that the Epstein-Barr virus (EBV) genome may be present in human lymphoblastoid cell lines that are free of detectable EBV1,2. We describe here a plentiful appearance of EBV-associated early antigens (EA) and the viral capsid antigen (VCA) in non-producing Raji and NC-37 cell lines when exposed to 5-bromodeoxyuridine (BUdR) or 5-iododeoxyuridine (IUdR). These antigens were synthesized in all the Raji and NC-37 clones exposed to BUdR or IUdR, strongly suggesting that a complete, but unexpressed, EBV genome exists in the cells of these non-producing lines.

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Authors and Affiliations

  1. Department of Virology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, N 15 W7

    KENJI SUGAWARA, FUMIO MIZUNO & TOYORO OSATO

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  1. KENJI SUGAWARA
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  2. FUMIO MIZUNO
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  3. TOYORO OSATO
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SUGAWARA, K., MIZUNO, F. & OSATO, T. Epstein-Barr Virus-associated Antigens in Non-producing Clones of Human Lymphoblastoid Cell Lines. Nature New Biology 239, 242–243 (1972). https://doi.org/10.1038/newbio239242a0

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