Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Drug Receptors and the Haemopoietic Stem Cell

Nature New Biology volume 241, pages 152–154 (1973)Cite this article

Abstract

THE pluripotent stem cell in the bone marrow of normal adult mice is in a resting stage (G0) or has a long cell cycle with only a small fraction occupied by DNA synthesis. These spleen colony forming cells1 or CFU-S2 are insensitive to the cytocidal action of high specific activity 3H-thymidine3.

This is a preview of subscription content, access via your institution

Access options

References

  1. Till, J. E., and McCulloch, E. A., Rad. Res., 14, 213 (1961).

    Article  CAS  Google Scholar 

  2. Sutherland, D. J. A., Till, J. E., and McCulloch, E. A., J. Cell. Physiol., 75, 267 (1970).

    Article  CAS  Google Scholar 

  3. Becker, A. J., McCulloch, E. A., Siminovitch, L., and Till, J. E., Blood, 26, 296 (1965).

    CAS  PubMed  Google Scholar 

  4. Byron, J. W., Nature, 228, 1204 (1970).

    Article  CAS  Google Scholar 

  5. Byron, J. W., Nature, 234, 39 (1971).

    Article  CAS  Google Scholar 

  6. Byron, J. W., Exp. Cell Res., 71, 228 (1972).

    Article  CAS  Google Scholar 

  7. MacKinney, jun., A. A., Stohlman, jun., F., and Brecher, G., Blood, 19, 349 (1962).

    PubMed  Google Scholar 

  8. Byron, J. W., and Lajtha, L. G., Blood, 20, 102 (1962).

    Google Scholar 

  9. Byron, J. W., Blood, 40, 198 (1972).

    CAS  PubMed  Google Scholar 

  10. Sheppard, H., and Wiggan, G., Biochem. Pharmacol., 20, 2128 (1971).

    Article  CAS  Google Scholar 

  11. Byron, J. W., Fifth International Congress on Pharmacology (San Francisco, 1972).

    Google Scholar 

  12. Hardman, J. G., Beavo, J. A., Gray, J. P., Chrisman, T. D., Patterson, W. D., and Sutherland, E. W., Ann. NY Acad. Sci., 185, 27 (1971).

    Article  CAS  Google Scholar 

  13. Mcllwain, H., Effects of Drugs on Cellular Control Mechanisms (edit. by Rabin, B. R., and Freedman, R. B.), 281 (Macmillan, London, 1971).

    Book  Google Scholar 

  14. Ferrendelli, J. A., Steiner, A. L., McDougal, jun., D. B., and Kipnis, D. M., Biochem. Biophys. Res. Comm., 41, 1061 (1970).

    Article  CAS  Google Scholar 

  15. Steiner, A. L., Pagliara, A. S., Chase, L. R., and Kipnis, D. M., J.Biol. Chem., 247,1114 (1972).

    CAS  PubMed  Google Scholar 

  16. Schultz, G., Jakobs, K. H., Bohme, E., and Schultz, K., Eur. J. Biochem., 24, 520 (1972).

    Article  CAS  Google Scholar 

  17. George, W. J., Polson, J. B., O'Toole, A. G., and Goldberg, N. D., Proc. Nat. Acad. Sci., Wash., 66, 398 (1970).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Haematology-Pharmacology Laboratory, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX

    J. W. BYRON

Authors
  1. J. W. BYRON
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BYRON, J. Drug Receptors and the Haemopoietic Stem Cell. Nature New Biology 241, 152–154 (1973). https://doi.org/10.1038/newbio241152a0

Download citation

  • Received:

  • Revised:

  • Issue date:

  • DOI: https://doi.org/10.1038/newbio241152a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing