Abstract
EXTERNAL application of proteases to axons has no effect on their electrophysiological properties1. Recently, enzymes such as pronase have been introduced into squid axons either to liquefy axoplasm as an aid in starting internal perfusion2, or to affect the system that inactivates Na conductance3. We have tested the effects of injecting various crystalline proteolytic enzymes of high purity; here we report the effect that injected trypsin has on the Na efflux from squid giant axons.
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References
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MULLINS, L., DE WEER, P. Changes in Sodium Transport induced by the Injection of Proteases into Squid Axons. Nature New Biology 243, 222–223 (1973). https://doi.org/10.1038/newbio243222a0
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DOI: https://doi.org/10.1038/newbio243222a0
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