Abstract
MULLINS et al. reply: Holmquist and Jukes have criticized the methodology and conclusions of our reported demonstration1 of sequence similarities between certain of the tRNAs and Escherichia coli 5S rRNA, contending that these homologies are artefactual because the number of gaps employed results in an unwieldy number of possible comparisons which can be made and that these gaps were inserted at different places in both molecules when different tRNAs were aligned with E. coli 5S rRNA.
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References
Mullins, jun., D. W., Lacey, jun., J. C., and Hearn, R. A., Nature new Biol., 242, 80 (1973).
Needleman, S. B., and Wunsch, C. D., J. molec. Biol., 48, 443 (1970).
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MULLINS, D., LACEY, J. & HEARN, R. No Evidence for a Common Evolutionary Origin of 5S rRNA and tRNA (Reply). Nature New Biology 245, 127–128 (1973). https://doi.org/10.1038/newbio245127b0
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DOI: https://doi.org/10.1038/newbio245127b0
