The discovery that a differentiated somatic cell can give rise to a new organism through nuclear transfer cloning touched off a revolution in genetics. A new study outlining how to target genes serially in cows ushers in a new era in large-animal genetics.
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References
Wilmut, I., Schnieke, A.E., McWhir, J. Kind, A.J. & Campbell, K.H. Nature 338, 810–813 (1997).
Kubota, C. et al. Proc. Natl. Acad. Sci. USA 97, 990–995 (2000).
Capecchi, M.R. Proc. Natl. Acad. Sci. USA 97, 956–957 (2000).
Kuroiwa, Y. et al. Nat. Genet. 36, 775–780 (2004).
Abuin, A. & Bradley, A. Mol. Cell. Biol. 16, 1851–1856 (1996).
Feng, Y.Q., Lorincz, M.C., Fiering, S., Greally, J.M. & Bouhassira, E.E. Mol. Cell. Biol. 21, 298–309 (2001).
Tian, X.C., Xu, J. & Yang, X. Nat. Genet. 26, 272–273 (2000).
Lanza, R.P. et al. Science 288, 665–669 (2000).
Kubota, C., Tian, X.C. & Yang, X. Nat. Biotechnol. 22, 693–694 (2004).
Wakayama, T. et al. Nature 407, 318–319 (2000).
Normile, D. Science 303, 1285 (2004).
Cyranoski, D. Nature 426, 743 (2003).
Costa, C. et al. Xenotransplantation 9, 45–57 (2002).
Phelps, C.J. et al. Science 299, 411–414 (2003).
Hardcastle, J., Harwood, M.D. & Taylor, C.J. J. Pharm. Pharmacol. 56, 329–338 (2004).
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Yang, X., Tian, X. & Fodor, W. Cattle call for gene targeting. Nat Genet 36, 671–672 (2004). https://doi.org/10.1038/ng0704-671
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DOI: https://doi.org/10.1038/ng0704-671