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Gene expression profile induced by leptin in white adipose tissue and liver

Nature Genetics volume 23, page 75 (1999)Cite this article

Leptin, the product of the ob gene, is a hormone that regulates body weight by decreasing food intake and increasing energy expenditure. After binding to its receptor in the hypothalamus and other tissues, leptin induces a novel metabolic response, which is physiologically distinct from food restriction alone. To better characterise this metabolic response, we monitored gene expression in lean and obese mice after leptin treatment or pair-feeding (food restriction) using Affymetrix GeneChips. We report the specific gene expression profile induced by leptin in white adipose tissue and liver. From these analyses, it is possible, for the first time, to distinguish leptin treatment from food restriction on a molecular level, as a number of genes are differentially expressed between the two states in the aforementioned tissues. This information will make it possible to further characterise leptin's novel metabolic effects and the efferent signals that coordinate them.

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  1. Laboratory of Molecular Genetics, Rockefeller University, New York, 10021, New York, USA

    Alexander Soukas, Paul Cohen & Jeffrey M. Friedman

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  1. Alexander Soukas
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  2. Paul Cohen
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  3. Jeffrey M. Friedman
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Soukas, A., Cohen, P. & Friedman, J. Gene expression profile induced by leptin in white adipose tissue and liver. Nat Genet 23 (Suppl 3), 75 (1999). https://doi.org/10.1038/14405

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